艾拉莫德

Tier C — Watch / trade

Iguratimod

江苏先声药业有限公司

Originator

2011

First approval

Expiry (public)

$0.07B ▲

Peak sales

化学药

Type

Targets：NF-κB

Brand：Careram、Iremod、Kolbet、Colvet、艾得辛

Indications (approved)：类风湿关节炎

Regional status

China

批准上市

2011-08-15

Japan

批准上市

2012-06-29

Synthetic routes & intermediates3 routes

Originator routes × 1Optimised (non-patent) × 0Process routes × 2

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 7 · Total yield 27.3 g

Code	CAS No.	Intermediate
IGUR-001	84594-96-7 Available	3-nitro-4-phenoxyphenol
IGUR-002	76838-77-2 Available	3-amino-4-phenoxyphenol
IGUR-003	123664-39-1 Available	N-(5-hydroxy-2-phenoxyphenyl)methanesulfonamide
IGUR-004	627-00-9 Available	4-chlorobutanoic acid
IGUR-005	123664-40-4 Available	3-(3-(methylsulfonamido)-4-phenoxyphenoxy)propanoic acid
IGUR-006	123664-21-1 Available	N-(4-oxo-6-phenoxychroman-7-yl)methanesulfonamide
IGUR-007	123664-34-6 Available	N-(3-bromo-4-oxo-6-phenoxychroman-7-yl)methanesulfonamide
IGUR-008	123663-48-9 Available	N-(3-amino-4-oxo-6-phenoxy-4H-chromen-7-yl)methanesulfonamide

ProcessRoute 2Steps 7 · Total yield 3.01 kg

Synthetic routes & intermediates Route 2

Code	CAS No.	Intermediate
IGUR-009	10298-80-3 Available	1-chloro-4-methoxy-2-nitrobenzene
IGUR-010	108-95-2 Available	phenol
IGUR-011	84594-95-6 Available	4-methoxy-2-nitro-1-phenoxybenzene
IGUR-012	76838-72-7 Available	5-methoxy-2-phenoxyaniline
IGUR-013	123664-84-6 Available	N-(5-methoxy-2-phenoxyphenyl)methanesulfonamide
IGUR-014	6011-14-9 Available	2-aminoacetonitrile hydrochloride
IGUR-015	759430-03-0 Available	N-(4-glycyl-5-methoxy-2-phenoxyphenyl)methanesulfonamide
IGUR-016	149456-98-4 Available	N-(2-(2-methoxy-4-(methylsulfonamido)-5-phenoxyphenyl)-2-oxoethyl)formamide
IGUR-017	149457-03-4 Available	N-(2-(2-hydroxy-4-(methylsulfonamido)-5-phenoxyphenyl)-2-oxoethyl)formamide
IGUR-018	4637-24-5 Available	1,1-dimethoxy-N,N-dimethylmethanamine

ProcessRoute 3Steps 9 · Total yield 2.11 kg

Synthetic routes & intermediates Route 3

Code	CAS No.	Intermediate
IGUR-006	123664-21-1 Available	N-(4-oxo-6-phenoxychroman-7-yl)methanesulfonamide
IGUR-007	123664-34-6 Available	N-(3-bromo-4-oxo-6-phenoxychroman-7-yl)methanesulfonamide
IGUR-009	10298-80-3 Available	1-chloro-4-methoxy-2-nitrobenzene
IGUR-010	108-95-2 Available	phenol
IGUR-011	84594-95-6 Available	4-methoxy-2-nitro-1-phenoxybenzene
IGUR-012	76838-72-7 Available	5-methoxy-2-phenoxyaniline
IGUR-013	123664-84-6 Available	N-(5-methoxy-2-phenoxyphenyl)methanesulfonamide
IGUR-019	123664-52-8 Available	N-(4-acetyl-5-hydroxy-2-phenoxyphenyl)methanesulfonamide
IGUR-020	123662-55-5 Available	N-(4-oxo-6-phenoxy-4H-chromen-7-yl)methanesulfonamide

Frequently asked questions

What are the approved indications of Iguratimod?

Approved indications include: 类风湿关节炎.

When does the Iguratimod patent expire?

No public expiry year is available for Iguratimod yet; this page updates once verified.

How many synthesis routes are recorded for Iguratimod?

3 synthesis routes are recorded; the shortest is 7 steps with 27.3 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Iguratimod intermediates?

20 intermediate CAS of Iguratimod are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Iguratimod intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24