奥吡卡朋
Tier C — Watch / tradeOpicapone
Targets：COMT
Brand：欧捷能、Ongentys
Indications (approved)：帕金森病、帕金森综合征
Regional status
Synthetic routes & intermediates2 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| OPIC-001 | 121-34-6Available | 4-hydroxy-3-methoxybenzoic acid |
| OPIC-002 | 15785-54-3 | 4-hydroxy-3-methoxy-5-nitrobenzoic acid |
| OPIC-003 | 84211-30-3 | 3,4-dihydroxy-5-nitrobenzoic acid |
| OPIC-004 | 923288-55-5 | 3,4-bis(benzyloxy)-5-nitrobenzoic acid |
| OPIC-005 | 896125-90-9 | (Z)-2,5-dichloro-N'-hydroxy-4,6-dimethylnicotinimidamide |
| OPIC-006 | 1229803-77-3 | (Z)-N'-((3,4-bis(benzyloxy)-5-nitrobenzoyl)oxy)-2,5-dichloro-4,6-dimethylnicotinimidamide |
| OPIC-007 | 1044136-99-3 | 5-(3,4-bis(benzyloxy)-5-nitrophenyl)-3-(2,5-dichloro-4,6-dimethylpyridin-3-yl)-1,2,4-oxadiazole |
| OPIC-008 | 1044137-00-9 | 3-(5-(3,4-bis(benzyloxy)-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-2,5-dichloro-4,6-dimethylpyridine 1-oxide |
| Code | CAS No. | Intermediate |
|---|---|---|
| OPIC-001 | 121-34-6Available | 4-hydroxy-3-methoxybenzoic acid |
| OPIC-002 | 15785-54-3 | 4-hydroxy-3-methoxy-5-nitrobenzoic acid |
| OPIC-005 | 896125-90-9 | (Z)-2,5-dichloro-N'-hydroxy-4,6-dimethylnicotinimidamide |
| OPIC-009 | 123-54-6 | pentane-2,4-dione |
| OPIC-010 | 107-91-5 | 2-cyanoacetamide |
| OPIC-011 | 769-28-8 | 4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile |
| OPIC-012 | 23819-92-3 | 5-chloro-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile |
| OPIC-013 | 91591-63-8 | 2,5-dichloro-4,6-dimethylnicotinonitrile |
| OPIC-014 | 1443319-15-0 | 4-hydroxy-3-methoxy-5-nitrobenzoyl chloride |
| OPIC-015 | 1391712-50-7 | 4-(3-(2,5-dichloro-4,6-dimethylpyridin-3-yl)-1,2,4-oxadiazol-5-yl)-2-methoxy-6-nitrophenol |
| OPIC-016 | 1402714-41-3 | 2,5-dichloro-3-(5-(4-hydroxy-3-methoxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-4,6-dimethylpyridine 1-oxide |
Frequently asked questions
What are the approved indications of Opicapone?
Approved indications include: 帕金森病, 帕金森综合征.
When does the Opicapone patent expire?
No public expiry year is available for Opicapone yet; this page updates once verified.
How many synthesis routes are recorded for Opicapone?
2 synthesis routes are recorded; the shortest is 7 steps with 0.172 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Opicapone intermediates?
1 intermediate CAS of Opicapone are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Opicapone intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24