Exemestane

Tier C — Watch / trade

Exemestane

Pfizer Inc.

Originator

1998

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：Aromatase

Brand：Aromasin, Nikidess

Indications (approved)：Breast cancer

Regional status

Approved

1999-10-21

Approved

1998-12-16

China

Approved

2002-01-11

Japan

Approved

2002-07-05

Factories producing this API1

Factories registered as producing this API in our sourcing network (RFQ records + product master), sorted by RFQ activity; the snapshot carries no cost or customer data.

1 producing factories on file — sign in to view the named list (factory details are not shown to guests).

Synthetic routes & intermediates3 routes

Originator routes × 1Optimised (non-patent) × 2Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 1 · Total yield 0.25 g

EXEM-00119457-55-7API · Exemestane

Code	CAS No.	Intermediate
EXEM-001	19457-55-7	(8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylene-7,8,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17(2H,6H)-dione

OptimisedRoute 2Steps 3 · Total yield /

EXEM-002897-06-3EXEM-003123-75-1EXEM-00467737-88-6EXEM-005184972-09-6API · Exemestane

Code	CAS No.	Intermediate
EXEM-002	897-06-3	(8R,9S,10R,13S,14S)-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,17(6H)-dione
EXEM-003	123-75-1	pyrrolidine
EXEM-004	67737-88-6	(1S,8R,9S,10R,13S,14S)-10,13-dimethyl-1,3-di(pyrrolidin-1-yl)-7,8,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17(2H)-one
EXEM-005	184972-09-6	(8R,9S,10R,13S,14S)-6-(hydroxymethyl)-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,17(6H)-dione

OptimisedRoute 3Steps 3 · Total yield 4.80 kg

EXEM-00119457-55-7EXEM-0061100-17-0EXEM-0071160599-91-6EXEM-008122370-91-6API · Exemestane

Code	CAS No.	Intermediate
EXEM-001	19457-55-7	(8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylene-7,8,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17(2H,6H)-dione
EXEM-006	1100-17-0	(8R,9S,10R,13S,14S,17S)-10,13-dimethyl-6-methylene-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate
EXEM-007	1160599-91-6	(8R,9S,10R,13S,14S,17S)-10,13-dimethyl-6-methylene-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl acetate
EXEM-008	122370-91-6	(8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-6-methylene-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

Frequently asked questions

What are the approved indications of Exemestane?

Approved indications include: Breast cancer.

When does the Exemestane patent expire?

No public expiry year is available for Exemestane yet; this page updates once verified.

How many synthesis routes are recorded for Exemestane?

3 synthesis routes are recorded; the shortest is 1 steps with 0.25 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Exemestane intermediates?

All intermediates in Exemestane routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Exemestane intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-27