甲苯磺酸奥马环素
Tier C — Watch / tradeOmadacycline tosylate · all drugs expiring in 2030 →
Targets：30S subunit
Brand：纽再乐、NUZYRA
Indications (approved)：皮肤和皮肤结构感染、社区获得性细菌肺炎、细菌感染、细菌性肺炎、细菌性皮肤疾病
Regional status
Synthetic routes & intermediates3 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| OMAD-001 | 389140-04-9 | (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-9-iodo-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide |
| OMAD-002 | 488818-70-8 | (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-9-formyl-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide |
| OMAD-003 | 5813-64-9 | 2,2-dimethylpropan-1-amine |
| Code | CAS No. | Intermediate |
|---|---|---|
| OMAD-004 | 13614-98-7 | (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride |
| OMAD-005 | 118-29-6 | 2-(hydroxymethyl)isoindoline-1,3-dione |
| OMAD-006a | 835877-67-3 | - |
| OMAD-006b | - | (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-N,9-bis((1,3-dioxoisoindolin-2-yl)methyl)-10-((1,3-dioxoisoindolin-2-yl)oxy)-3,12,12a-trihydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide |
| OMAD-007 | 19532-98-0 | N1,N2-dimethylphthalamide |
| OMAD-008a | 488820-34-4 | - |
| OMAD-008b | 835877-68-4 | - |
| OMAD-009 | 630-19-3 | pivalaldehyde |
| Code | CAS No. | Intermediate |
|---|---|---|
| OMAD-003 | 5813-64-9 | 2,2-dimethylpropan-1-amine |
| OMAD-004 | 13614-98-7 | (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride |
| OMAD-010 | 162150-89-2 | 1,3,5-trineopentyl-1,3,5-triazinane |
| OMAD-011 | 541-88-8Available | 2-chloroacetic anhydride |
| OMAD-012 | 1075240-46-8 | (2-chloro-N-neopentylacetamido)methyl 2-chloroacetate |
| OMAD-013 | 1075240-41-3 | (4S,4aS,5aR,12aS)-9-((2-chloro-N-neopentylacetamido)methyl)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-N-(hydroxymethyl)-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide |
| OMAD-014 | - | (4aS,5aR,12aS)-9-((2-chloro-N-neopentylacetamido)methyl)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide |
Frequently asked questions
What are the approved indications of Omadacycline tosylate?
Approved indications include: 皮肤和皮肤结构感染, 社区获得性细菌肺炎, 细菌感染, 细菌性肺炎, 细菌性皮肤疾病.
When does the Omadacycline tosylate patent expire?
Based on public sources, the Omadacycline tosylate patent expires in 2030.
How many synthesis routes are recorded for Omadacycline tosylate?
3 synthesis routes are recorded; the shortest is 2 steps with 5.41 g total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Omadacycline tosylate intermediates?
1 intermediate CAS of Omadacycline tosylate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Omadacycline tosylate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24