贝美替尼
Tier C — Watch / tradeBinimetinib
Targets：MEK2、MEK1
Brand：Mektovi、MEKTOVI、美妥维
Indications (approved)：非小细胞肺癌、黑色素瘤
Regional status
Synthetic routes & intermediates2 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| BINI-001 | 61079-72-9 | 2,3,4-trifluorobenzoic acid |
| BINI-002 | 197520-71-1 | 2,3,4-trifluoro-5-nitrobenzoic acid |
| BINI-003 | 284030-57-5 | 4-amino-2,3-difluoro-5-nitrobenzoic acid |
| BINI-004 | 284030-58-6 | methyl 4-amino-2,3-difluoro-5-nitrobenzoate |
| BINI-005 | 348-54-9 | 2-fluoroaniline |
| BINI-006 | 606143-94-6 | methyl 4-amino-3-fluoro-2-((2-fluorophenyl)amino)-5-nitrobenzoate |
| BINI-007 | - | methyl 4-fluoro-5-((2-fluorophenyl)amino)-1H-benzo[d]imidazole-6-carboxylate |
| BINI-008 | 606143-48-0 | methyl 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1H-benzo[d]imidazole-6-carboxylate |
| BINI-009 | 1415559-93-1 | methyl 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate |
| BINI-010 | 1415564-99-6 | 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylic acid |
| BINI-011 | 391212-29-6 | methyl 2-((2-fluoro-4-iodophenyl)amino)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate |
| BINI-012 | 1415559-75-9 | 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-N-(2-(vinyloxy)ethoxy)-1H-benzo[d]imidazole-6-carboxamide |
| Code | CAS No. | Intermediate |
|---|---|---|
| BINI-001 | 61079-72-9 | 2,3,4-trifluorobenzoic acid |
| BINI-002 | 197520-71-1 | 2,3,4-trifluoro-5-nitrobenzoic acid |
| BINI-003 | 284030-57-5 | 4-amino-2,3-difluoro-5-nitrobenzoic acid |
| BINI-004 | 284030-58-6 | methyl 4-amino-2,3-difluoro-5-nitrobenzoate |
| BINI-009 | 1415559-93-1 | methyl 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate |
| BINI-013 | 918321-18-3 | methyl 2,4-diamino-3-fluoro-5-nitrobenzoate |
| BINI-014 | 918321-27-4 | methyl 2,4,5-triamino-3-fluorobenzoate |
| BINI-015 | 462-95-3 | diethoxymethane |
| BINI-016 | 918321-20-7 | methyl 5-amino-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate |
| BINI-017 | 105931-73-5Available | 4-bromo-2-fluoro-1-iodobenzene |
| BINI-018 | 1604812-72-7 | potassium 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxylate |
| BINI-019 | 1604812-73-8 | (5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-1-methyl-1H-benzo[d]imidazol-6-yl)(1H-imidazol-1-yl)methanone |
| BINI-020 | 1023742-13-3 | O-(2-(tert-butoxy)ethyl)hydroxylamine |
| BINI-021 | 1604812-71-6 | 5-((4-bromo-2-fluorophenyl)amino)-N-(2-(tert-butoxy)ethoxy)-4-fluoro-1-methyl-1H-benzo[d]imidazole-6-carboxamide hydrate |
Frequently asked questions
What are the approved indications of Binimetinib?
Approved indications include: 非小细胞肺癌, 黑色素瘤.
When does the Binimetinib patent expire?
No public expiry year is available for Binimetinib yet; this page updates once verified.
How many synthesis routes are recorded for Binimetinib?
2 synthesis routes are recorded; the shortest is 10 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Binimetinib intermediates?
1 intermediate CAS of Binimetinib are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Binimetinib intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24