苯磺酸美洛加巴林

Tier C — Watch / trade

Mirogabalin besilate · all drugs expiring in 2030 →

第一三共株式会社

Originator

2019

First approval

2030

Expiry (public)

$0.44B ▲

Peak sales

化学药

Type

Targets：CACNA2D1

Brand：德力静、Tarlige

Indications (approved)：糖尿病神经病变、疱疹后神经痛、周围神经系统疾病

Regional status

无进展

2014-10-27

无进展

2014-10-27

China

批准上市

2024-06-28

Japan

批准上市

2019-01-08

Synthetic routes & intermediates2 routes

Originator routes × 1Optimised (non-patent) × 1Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 7 · Total yield 2.14 g

Code	CAS No.	Intermediate
MRIO-001	106-95-6 Available	3-bromoprop-1-ene
MRIO-002	106-95-6 Available	3-bromoprop-1-ene
MRIO-003	1138245-48-3 Available	ethyl 4-ethyl-3-hydroxyhept-6-enoate
MRIO-004	1138245-49-4 Available	4-ethyl-3-hydroxyhept-6-enoic acid
MRIO-005	62327-21-3 Available	tert-butyl 2-(dimethoxyphosphoryl)acetate
MRIO-006	1138245-50-7 Available	(E)-tert-butyl 2-(3-ethylbicyclo[3.2.0]hept-3-en-6-ylidene)acetate
MRIO-007	1415817-42-3 Available	tert-butyl 2-(3-ethyl-6-(nitromethyl)bicyclo[3.2.0]hept-3-en-6-yl)acetate
MRIO-008	1138246-18-0 Available	tert-butyl 2-((1R,5S,6S)-3-ethyl-6-(nitromethyl)bicyclo[3.2.0]hept-3-en-6-yl)acetate
MRIO-009	1138246-20-4 Available	tert-butyl 2-((1R,5S,6S)-6-(((tert-butoxycarbonyl)amino)methyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetate

OptimisedRoute 2Steps 5 · Total yield 36.19 g

Synthetic routes & intermediates Route 2

Code	CAS No.	Intermediate
MRIO-010	1235479-61-4 Available	(1R,5S)-3-ethylbicyclo[3.2.0]hept-3-en-6-one
MRIO-011	105-53-3 Available	diethyl malonate
MRIO-012	1644251-28-4 Available	diethyl 2-((1R,5S)-3-ethylbicyclo[3.2.0]hept-3-en-6-ylidene)malonate
MRIO-013	1644251-34-2 Available	diethyl 2-((1R,5S,6R)-6-cyano-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)malonate
MRIO-014	1644251-58-0 Available	2-((1R,5S,6S)-6-cyano-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetic acid
MRIO-015	1644251-62-6 Available	phenylmethanamine 2-((1R,5S,6S)-6-cyano-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetate

Frequently asked questions

What are the approved indications of Mirogabalin besilate?

Approved indications include: 糖尿病神经病变, 疱疹后神经痛, 周围神经系统疾病.

When does the Mirogabalin besilate patent expire?

Based on public sources, the Mirogabalin besilate patent expires in 2030.

How many synthesis routes are recorded for Mirogabalin besilate?

2 synthesis routes are recorded; the shortest is 5 steps with 36.19 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Mirogabalin besilate intermediates?

14 intermediate CAS of Mirogabalin besilate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Mirogabalin besilate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24