阿伐替尼
Tier C — Watch / tradeAvapritinib · all drugs expiring in 2032 →
Targets：KIT、PDGFR-α
Brand：泰吉华、Ayvakit、Ayvakyt、Taijihua
Indications (approved)：系统性肥大细胞增多症、胃肠道间质瘤、肥大细胞白血病
Regional status
Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| AVAPR-015 | 1703794-88-0Available | 1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethan-1-amine |
| AVAPR-016 | 888721-83-3Available | 6-bromopyrrolo[2,1-f][1,2,4]triazin-4(3H)-one |
| AVAPR-017 | 761446-44-0Available | 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole |
| AVAPR-018 | 1703794-32-4Available | 6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one |
| Avapritinib | - | (S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethan-1-amine |
| AVAPR-001 | 89793-12-4Available | ethyl 2-chloropyrimidine-5-carboxylate |
| AVAPR-002 | 57260-71-6Available | tert-butyl piperazine-1-carboxylate |
| AVAPR-003 | 253315-69-4Available | ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrimidine-5-carboxylate |
| AVAPR-004 | 253315-11-6Available | 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrimidine-5-carboxylic acid |
| AVAPR-005 | 1117-97-1Available | N,O-dimethylhydroxylamine |
| AVAPR-006 | 1703794-70-0Available | tert-butyl 4-(5-(methoxy(methyl)carbamoyl)pyrimidin-2-yl)piperazine-1-carboxylate |
| AVAPR-007 | 352-13-6Available | (4-fluorophenyl)magnesium bromide |
| AVAPR-008 | 1703794-73-3Available | tert-butyl 4-(5-(4-fluorobenzoyl)pyrimidin-2-yl)piperazine-1-carboxylate |
| AVAPR-009 | 1703795-52-1Available | (4-fluorophenyl)(2-(piperazin-1-yl)pyrimidin-5-yl)methanone hydrochloride |
| AVAPR-010 | 1703794-33-5Available | 4-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazine |
| AVAPR-011 | 1703794-85-7Available | (4-fluorophenyl)(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)methanone |
| AVAPR-012 | 343338-28-3Available | (S)-2-methylpropane-2-sulfinamide |
| AVAPR-013 | 1703794-86-8Available | (Z)-N-((4-fluorophenyl)(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)methylene)-2-methylpropane-2-sulfinamide |
| AVAPR-014 | 1703794-87-9Available | N-(1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethyl)-2-methylpropane-2-sulfinamide |
Frequently asked questions
What are the approved indications of Avapritinib?
Approved indications include: 系统性肥大细胞增多症, 胃肠道间质瘤, 肥大细胞白血病.
When does the Avapritinib patent expire?
Based on public sources, the Avapritinib patent expires in 2032.
How many synthesis routes are recorded for Avapritinib?
1 synthesis routes are recorded; the shortest is 12 steps with 32.1 mg total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Avapritinib intermediates?
18 intermediate CAS of Avapritinib are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Avapritinib intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24