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Diroximel fumarate

Tier C — Watch / trade

Diroximel fumarate

Alkermes Plc
Originator
2019
First approval
-
Expiry (public)
$0.75B ▲
Peak sales
化学药
Type

Targets:Nrf2

Brand:Vumerity

Indications (approved):多发性硬化、复发-缓解型多发性硬化

Regional status

US
批准上市
2019-10-29
EU
批准上市
2021-11-15
China
临床三期
2021-11-18
Japan
批准上市
2026-06-19

Synthetic routes & intermediates1 routes

Originator routes × 1Optimised (non-patent) × 0Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 1 · Total yield 1.03 g
Synthetic routes & intermediates Route 1
CodeCAS No.Intermediate
MONO-0012759-87-8(E)-4-methoxy-4-oxobut-2-enoic acid
MONO-00218190-44-81-(2-hydroxyethyl)pyrrolidine-2,5-dione

Frequently asked questions

What are the approved indications of Diroximel fumarate?

Approved indications include: 多发性硬化, 复发-缓解型多发性硬化.

When does the Diroximel fumarate patent expire?

No public expiry year is available for Diroximel fumarate yet; this page updates once verified.

How many synthesis routes are recorded for Diroximel fumarate?

1 synthesis routes are recorded; the shortest is 1 steps with 1.03 g total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Diroximel fumarate intermediates?

All intermediates in Diroximel fumarate routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.

How do I get a quote for Diroximel fumarate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24