Amlodipine Maleate

Tier C — Watch / trade

Amlodipine Maleate

Dr. Reddy's Laboratories Ltd.

Originator

2003

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：VDCCs

Brand：Amvaz

Indications (approved)：Hypertension, Angina pectoris

Regional status

Withdrawn

No progress

2003-04-01

China

Approved

Japan

Synthetic routes & intermediates2 routes

Originator routes × 0Optimised (non-patent) × 2Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 6 · Total yield /

(Ia)109067-10-a141-43-5(Ib)109067-10-a107-07-3(II)109067-10-a3891-07-4(III)109067-10-a638-07-3(IV)109067-10-a13176-46-0(V)109067-10-a,(V)109067-10-b88150-75-8(VI)109067-10-a89-98-5(VII)109067-10-a—(VIII)109067-10-a14205-39-1(IX)109067-10-a103094-30-0,88150-62-3(X)109067-10-a88150-42-9,111470-99-6API · Amlodipine Maleate

Code	CAS No.	Intermediate
(Ia)109067-10-a	141-43-5 Available	2-Aminoethyl alcohol
(Ib)109067-10-a	107-07-3	2-Chloroethanol
(II)109067-10-a	3891-07-4	2-(2-Hydroxyethyl)-1H-isoindole-1,3(2H)-dione
(III)109067-10-a	638-07-3	Ethyl 4-chloro-3-oxobutanoate
(IV)109067-10-a	13176-46-0	Ethyl 4-bromoacetoacetate
(V)109067-10-a,(V)109067-10-b	88150-75-8	Ethyl 4-(2-phthalimidoethoxy)acetoacetate
(VI)109067-10-a	89-98-5	2-Chlorobenzaldehyde
(VII)109067-10-a	-	2-(2-Chlorobenzylidene)-4-(2-phthalimidoethoxy)acetoacetic acid ethyl ester
(VIII)109067-10-a	14205-39-1	3-Amino-2-butenoic acid methyl ester
(IX)109067-10-a	103094-30-0,88150-62-3	3-Ethyl 5-methyl (4RS)-4-(2-chlorophenyl)-2-[[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(X)109067-10-a	88150-42-9,111470-99-6	3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

OptimisedRoute 2Steps 2 · Total yield /

Code	CAS No.	Intermediate
(Ia)109067-10-a	141-43-5 Available	2-Aminoethyl alcohol
(Ib)109067-10-a	107-07-3	2-Chloroethanol
(II)109067-10-a	3891-07-4	2-(2-Hydroxyethyl)-1H-isoindole-1,3(2H)-dione
(III)109067-10-a	638-07-3	Ethyl 4-chloro-3-oxobutanoate
(IV)109067-10-a	13176-46-0	Ethyl 4-bromoacetoacetate
(V)109067-10-a,(V)109067-10-b	88150-75-8	Ethyl 4-(2-phthalimidoethoxy)acetoacetate
(VI)109067-10-a	89-98-5	2-Chlorobenzaldehyde
(VII)109067-10-a	-	2-(2-Chlorobenzylidene)-4-(2-phthalimidoethoxy)acetoacetic acid ethyl ester
(VIII)109067-10-a	14205-39-1	3-Amino-2-butenoic acid methyl ester
(IX)109067-10-a	103094-30-0,88150-62-3	3-Ethyl 5-methyl (4RS)-4-(2-chlorophenyl)-2-[[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(X)109067-10-a	88150-42-9,111470-99-6	3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Frequently asked questions

What are the approved indications of Amlodipine Maleate?

Approved indications include: Hypertension, Angina pectoris.

When does the Amlodipine Maleate patent expire?

No public expiry year is available for Amlodipine Maleate yet; this page updates once verified.

How many synthesis routes are recorded for Amlodipine Maleate?

2 synthesis routes are recorded; the shortest is 2 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Amlodipine Maleate intermediates?

1 intermediate CAS of Amlodipine Maleate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Amlodipine Maleate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-27