比克替拉韦

Tier B — Position early

Bictegravir · all drugs expiring in 2033 →

Gilead Inc

Originator

First approval

2033

Expiry (public)

$12B *

Peak sales

化学药

Type

Targets：HIV integrase

Indications (approved)：HIV感染

Regional status

临床三期

2016-09-21

临床三期

2022-08-16

China

Japan

临床三期

2022-08-16

Synthetic routes & intermediates1 routes

Originator routes × 1Optimised (non-patent) × 0Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 4 · Total yield /

Code	CAS No.	Intermediate
BICTE-001	1335210-23-5 Available	1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid
BICTE-002	1616340-75-0 Available	1-(2,2-dihydroxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid
BICTE-003	1110772-05-8 Available	(1R,3S)-3-aminocyclopentan-1-ol
BICTE-004	-	(2R,5S,13aR)-8-methoxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxylic acid
BICTE-005	214759-21-4 Available	(2,4,6-trifluorophenyl)methanamine
BICTE-006	-	(2R,5S,13aR)-8-methoxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
Bictegravir	1611493-60-7 Available	(2R,5S,13aR)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide

Frequently asked questions

What are the approved indications of Bictegravir?

Approved indications include: HIV感染.

When does the Bictegravir patent expire?

Based on public sources, the Bictegravir patent expires in 2033.

How many synthesis routes are recorded for Bictegravir?

1 synthesis routes are recorded; the shortest is 4 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Bictegravir intermediates?

5 intermediate CAS of Bictegravir are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Bictegravir intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24