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CAS 1005450-55-4
(R)-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propanamide
Codes: CINA-015
Application context (from source-drug indications)
HypercalcaemiaCinacalcet HydrochlorideSecondary hyperparathyroidismCinacalcet HydrochlorideHyperparathyroidismCinacalcet HydrochloridePrimary hyperparathyroidismCinacalcet HydrochlorideChronic renal impairmentCinacalcet HydrochlorideCardiogenic oedemaCinacalcet Hydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Cinacalcet Hydrochloride | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(R)-1-(naphthalen-1-yl)ethan-1-amine→3-(trifluoromethyl)benzaldehyde→acetic anhydride→(E)-3-(3-(trifluoromethyl)phenyl)acrylic acid→3-(3-(trifluoromethyl)phenyl)propanoic acid→(R)-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propanamide
(R)-1-(naphthalen-1-yl)ethan-1-amine→3-(3-(trifluoromethyl)phenyl)propanoic acid→(R)-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propanamide→3-(trifluoromethyl)aniline→acrylonitrile→2-chloro-3-(3-(trifluoromethyl)phenyl)propanenitrile→2-chloro-3-(3-(trifluoromethyl)phenyl)propanoic acid
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