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CAS 101-02-0
Phenyl phosphite
Codes：Tenofovir disoproxil phosphate-050
Application context (from source-drug indications)
HIV感染拉米夫定/富马酸替诺福韦二吡呋酯慢性乙型肝炎拉米夫定/富马酸替诺福韦二吡呋酯HIV感染依非韦伦/拉米夫定/富马酸替诺福韦二吡呋酯HIV感染恩曲他滨/盐酸利匹韦林/富马酸替诺福韦二吡呋酯
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 拉米夫定/富马酸替诺福韦二吡呋酯Lamivudine/Tenofovir Disoproxil Fumarate | Tier C — Watch / trade | - |
| 依非韦伦/拉米夫定/富马酸替诺福韦二吡呋酯Efavirenz/Lamivudine/Tenofovir Disoproxil Fumarate | Tier C — Watch / trade | - |
| 恩曲他滨/盐酸利匹韦林/富马酸替诺福韦二吡呋酯Emtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil Fumarate | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
([[(2R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonic acid→Phenyl phosphite→Phenyl hydrogen ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→Diphenyliodanium trifluoromethanesulfonate→Diphenyliodanium methanesulfonate→Diphenyliodanium tetrafluoridoborate(1-)→Diphenyliodonium hexafluorophosphate→Diphenyliodanium hexafluoridoarsenate(1-)→Diphenyliodanium nitrate→Diphenyliodanium fluoride→Diphenyliodanium bromide
([[(2R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonic acid→Phenyl phosphite→Phenyl hydrogen ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→Diphenyliodanium trifluoromethanesulfonate→Diphenyliodanium methanesulfonate→Diphenyliodanium tetrafluoridoborate(1-)→Diphenyliodonium hexafluorophosphate→Diphenyliodanium hexafluoridoarsenate(1-)→Diphenyliodanium nitrate→Diphenyliodanium fluoride→Diphenyliodanium bromide
([[(2R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonic acid→Phenyl phosphite→Phenyl hydrogen ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate→Diphenyliodanium trifluoromethanesulfonate→Diphenyliodanium methanesulfonate→Diphenyliodanium tetrafluoridoborate(1-)→Diphenyliodonium hexafluorophosphate→Diphenyliodanium hexafluoridoarsenate(1-)→Diphenyliodanium nitrate→Diphenyliodanium fluoride→Diphenyliodanium bromide
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