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CAS 1030838-88-0

5-[(2-Oxocyclopentyl)methyl]imidazolidine-2,4-dione

Codes:Ramipril-050

Application context (from source-drug indications)

高胆固醇血症阿托伐他汀钙/雷米普利高血压阿托伐他汀钙/雷米普利

Source drugs (routes using this intermediate)

DrugTierExpiry
阿托伐他汀钙/雷米普利Atorvastatin Calcium Hydrate/RamiprilTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

阿托伐他汀钙/雷米普利优化路线steps: 6total yield: 11.8g(Ramipril (Free))
5-[(2-Oxocyclopentyl)methyl]imidazolidine-2,4-dione→3-(2-Oxocyclopentyl)-L-alanine→(2S,3aS,6aS)-Octahydrocyclopenta[b]pyrrole-2-carboxylic acid→Benzyl (2S,3aS,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride→Benzyl (2S,3aS,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylate→Ethyl (2S)-2-[[(2S)-1-chloro-1-oxopropan-2-yl]amino]-4-phenylbutanoate hydrochloride→N-[(S)-(+)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanine

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