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CAS 1033517-33-7
(2R,4S,5R)-2-Tert-butyl-4-phenyl-1,3-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl 5-methyl ester
Codes：(IIIb)140605-16-a
Application context (from source-drug indications)
膀胱癌多西他赛纳米胶束 (Samyang Biopharmaceuticals)头颈癌多西他赛纳米胶束 (Samyang Biopharmaceuticals)头颈部鳞状细胞癌多西他赛纳米胶束 (Samyang Biopharmaceuticals)实体瘤多西他赛纳米胶束 (Samyang Biopharmaceuticals)
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 多西他赛纳米胶束 (Samyang Biopharmaceuticals)Docetaxel polymeric micelle (Samyang Biopharmaceuticals) | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Formic acid→2-Methylpropanal→2,2-Dimethylpropanal→(2R,4S,5R)-2-Isopropyl-4-phenyl-1,3-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl 5-methyl ester→(2R,4S,5R)-2-Tert-butyl-4-phenyl-1,3-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl 5-methyl ester→(2R,4S,5R)-3-[(Tert-butoxy)carbonyl]-2-isopropyl-4-phenyl-1,3-oxazolidine-5-carboxylic acid→(2R,4S,5R)-3-[(Tert-butoxy)carbonyl]-2-tert-butyl-4-phenyl-1,3-oxazolidine-5-carboxylic acid→(2alpha,5beta,7beta,10beta,13alpha)-4-(Acetyloxy)-2-(benzoyloxy)-1,13-dihydroxy-9-oxo-5,20-epoxytax-11-ene-7,10-diyl bis(3,5-dinitrobenzoate)→5-[(2alpha,5beta,7beta,10beta,13alpha)-4-(Acetyloxy)-2-(benzoyloxy)-7,10-bis[(3,5-dinitrobenzoyl)oxy]-1-hydroxy-9-oxo-5,20-epoxytax-11-en-13-yl] 3-tert-butyl (2R,4S,5R)-4-phenyl-2-(propan-2-yl)-1,3-oxazolidine-3,5-dicarboxylate→(VIb)140605-16-a→Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-4,6-bis[(3,5-dinitrobenzoyl)oxy]-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-→3,5-Dinitrobenzoyl chloride→(2alpha,5beta,7beta,10beta,13alpha)-4-(Acetyloxy)-1,7,10,13-tetrahydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate→1-tert-Butyl-3-ethyl 4-oxopiperidine-1,3-dicarboxylate
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