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CAS 1034305-27-5
(2S,3R,4S,5R,6R)-6-(acetoxymethyl)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triyl triacetate
Codes：IPRA-014
Application context (from source-drug indications)
二型糖尿病磷酸西格列汀一水合物/伊格列净L-脯氨酸盐
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 磷酸西格列汀一水合物/伊格列净L-脯氨酸盐Sitagliptin Phosphate Monohydrate/Ipragliflozin L-Proline | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
5-bromo-2-fluorobenzaldehyde→benzo[b]thiophene→benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol→2-(5-bromo-2-fluorobenzyl)benzo[b]thiophene→2-((5-bromo-2-fluorophenyl)chloromethyl)benzo[b]thiophene→(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one→(2S,3R,4S,5S,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol→(2S,3R,4S,5R,6R)-6-(acetoxymethyl)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triyl triacetate→(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate→(S)-pyrrolidine-2-carboxylic acid
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