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CAS 104618-33-9
2-(2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)isoindoline-1,3-dione
Codes: PRAM-007
Application context (from source-drug indications)
Restless legs syndromePramipexole Dihydrochloride HydrateParkinson's diseasePramipexole Dihydrochloride HydrateManiaPramipexole Dihydrochloride Hydrate快感缺乏Pramipexole Dihydrochloride HydrateDepressionPramipexole Dihydrochloride HydrateMajor depressive disorderPramipexole Dihydrochloride Hydrate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Pramipexole Dihydrochloride Hydrate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-(4-oxocyclohexyl)isoindoline-1,3-dione→2-(2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)isoindoline-1,3-dione→PRAM-008
(S)-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine→2-(2-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)isoindoline-1,3-dione→PRAM-008→2-(4-hydroxycyclohexyl)isoindoline-1,3-dione→4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine (2R,3R)-2,3-dihydroxysuccinate→(S)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine
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