← Back to patent-cliff list
CAS 105-50-0
1,3-Acetonedicarboxylic acid diethyl ester
Codes：(I)819703-1-a
Application context (from source-drug indications)
胃肠道间质瘤瑞派替尼
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 瑞派替尼Ripretinib | Tier C — Watch / trade | 2032 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1,3-Acetonedicarboxylic acid diethyl ester→4,6-Dihydroxynicotinic acid ethyl ester→2,4-Dichloro-5-carbethoxypyridine→Aminoethane→6-Chloro-4-ethylamino-nicotinic acid ethyl ester→[6-Chloro-4-(ethylamino)pyridin-3-yl]methanol→6-Chloro-4-(ethylamino)nicotinaldehyde→Ethyl (5-amino-2-bromo-4-fluorophenyl)acetate→3-(5-Amino-2-bromo-4-fluorophenyl)-7-chloro-1-ethyl-1,6-naphthyridin-2(1H)-one→Aminomethane→3-(5-Amino-2-bromo-4-fluorophenyl)-1-ethyl-7-(methylamino)-1,6-naphthyridin-2(1H)-one→3-(5-Amino-2-bromo-4-fluorophenyl)-1-ethyl-7-(methylamino)-1,6-naphthyridin-2(1H)-one hydrochloride→4-Isocyanatobenzene→Carbanilic acid phenyl ester→2-(2-Bromo-4-fluorophenyl)acetic acid→(2-Bromo-4-fluoro-5-nitrophenyl)acetic acid→Ethyl (2-bromo-4-fluoro-5-nitrophenyl)acetate
Intermediates available on this site
No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.