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CAS 108-30-5

2,5-Dioxotetrahydrofuran

Codes：SALM-029、(IV)91299-1-a

Application context (from source-drug indications)

哮喘布地奈德/昔萘酸沙美特罗疟原虫感染青蒿琥酯/磷酸咯萘啶新型冠状病毒感染青蒿琥酯/磷酸咯萘啶恶性疟青蒿琥酯/磷酸咯萘啶疟原虫感染青蒿琥酯/盐酸甲氟喹恶性疟青蒿琥酯/盐酸甲氟喹

Source drugs (routes using this intermediate)

DrugTierExpiry
布地奈德/昔萘酸沙美特罗Budesonide/Salmeterol xinafoateTier C — Watch / trade-
青蒿琥酯/磷酸咯萘啶Artesunate/Pyronaridine PhosphateTier C — Watch / trade-
青蒿琥酯/盐酸甲氟喹Artesunate/Mefloquine HydrochlorideTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

布地奈德/昔萘酸沙美特罗优化路线steps: 11total yield: 1.3 g (Salmeterol xinafoate)
SALM-025→methyl 5-acetyl-2-hydroxybenzoate→SALM-026→SALM-027→N-benzyl-6-(4-phenylbutoxy)hexan-1-amine→SALM-028→SALM-029→SALM-030→SALM-031→SALM-032→4-phenylbutan-1-ol→SALM-033→SALM-034
青蒿琥酯/磷酸咯萘啶优化路线steps: 3total yield: /
Dihydroartemisinic acid→(1R,4S,5R,8S,9R,12S,13R)-1,5,9-Trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-one→(1R,4S,5R,8S,9R,12R,13R)-1,5,9-Trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol→2,5-Dioxotetrahydrofuran
青蒿琥酯/盐酸甲氟喹优化路线steps: 3total yield: /
Dihydroartemisinic acid→(1R,4S,5R,8S,9R,12S,13R)-1,5,9-Trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-one→(1R,4S,5R,8S,9R,12R,13R)-1,5,9-Trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol→2,5-Dioxotetrahydrofuran

Intermediates available on this site

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