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CAS 1108745-07-8
5-((3,5-difluorophenyl)(hydroxy)methyl)-2-fluorobenzonitrile
Codes：ENTR-003
Application context (from source-drug indications)
实体瘤恩曲替尼非小细胞肺癌恩曲替尼
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 恩曲替尼Entrectinib | Tier C — Watch / trade | 2030 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-bromo-3,5-difluorobenzene→2-fluoro-5-formylbenzonitrile→5-((3,5-difluorophenyl)(hydroxy)methyl)-2-fluorobenzonitrile→5-(3,5-difluorobenzoyl)-2-fluorobenzonitrile→(3-amino-1H-indazol-5-yl)(3,5-difluorophenyl)methanone→N-(5-(3,5-difluorobenzoyl)-1H-indazol-3-yl)-2,2,2-trifluoroacetamide→N-(5-(3,5-difluorobenzoyl)-1-trityl-1H-indazol-3-yl)-2,2,2-trifluoroacetamide→(3-amino-1-trityl-1H-indazol-5-yl)(3,5-difluorophenyl)methanone→4-(4-methylpiperazin-1-yl)-2-nitrobenzoic acid hydrochloride→N-(5-(3,5-difluorobenzoyl)-1-trityl-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)-2-nitrobenzamide→N-(5-(3,5-difluorobenzoyl)-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)-2-nitrobenzamide→N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)-2-nitrobenzamide→2-amino-N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)benzamide→tetrahydro-4H-pyran-4-one
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications |
|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | 5-(3,5-difluorobenzyl)-1H-indazol-3-amine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | tert-butyl 4-(4-methylpiperazin-1-yl)-2-nitrobenzoate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | 5-(3,5-difluorobenzyl)-2-fluorobenzonitrile Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | tert-butyl 2-amino-4-(4-methylpiperazin-1-yl)benzoate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | 4-(4-methylpiperazin-1-yl)-2-[(tetrahydropyran-4-yl)(2,2,2-trifluoroacetyl)amino]benzoic acid trifluoroacetate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | 4-(4-methylpiperazin-1-yl)-2-(2,2,2-trifluoro-N-(tetrahydro-2H-pyran-4-yl)acetamido)benzoicacid Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.