CAS 112885-41-3

Codes: Mosapride Citrate-007

Application context (from source-drug indications)

GastritisMosapride CitrateEnteral feeding intoleranceMosapride CitrateIrritable bowel syndromeMosapride CitrateDyspepsiaMosapride CitrateConstipationMosapride Citrate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Mosapride Citrate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Mosapride CitrateOptimised routesteps: 5total yield: /

Methyl 4-(acetylamino)-2-hydroxybenzoate→1-Iodoethane→methyl 4-acetamido-2-ethoxybenzoate→methyl 5-chloro-4-acetamido-2-ethoxybenzoate→4-Amino-5-chloro-2-ethoxybenzoic acid→[4-(4-Fluorobenzyl)-2-morpholinyl]methylamine→Mosapride Citrate-007

Mosapride CitrateOptimised routesteps: 4total yield: /

Sulfuric acid 1-[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methanamine→Phosphoric acid 1-[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methanamine→1-[4-[(4-Fluorophenyl)methyl]morpholin-2-yl]methanamine hydrogen chloride→2-Methylpropane-1,2,3-tricarboxylic acid 1-[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methanamine→Mosapride Citrate-007→Sodium 4-amino-2-hydroxybenzoate→N-Acetyl-4-aminosalicylic acid→1-Bromoethane→Ethyl 4-acetamido-2-ethoxybenzoate→Ethyl 4-acetamido-5-chloro-2-ethoxybenzoate

Mosapride CitrateOptimised routesteps: 6total yield: 54.6g(Mosapride Citrate (API))

2-Fluoro-4-nitrobenzenecarboxylic acid→Methyl 2-fluoro-4-nitrobenzenecarboxylate→Ethanol sodium salt→Methyl 2-ethoxy-4-nitrobenzoate→Methyl 5-chloro-2-ethoxy-4-nitrobenzoate→[4-(4-Fluorobenzyl)-2-morpholinyl]methylamine→Mosapride Citrate-007

Mosapride CitrateOptimised routesteps: 7total yield: 15.5g(Mosapride (Free))

1-Chloro-2-methylbenzene→2-Chloro-1-methyl-4-nitrobenzene→Potassium ethanolate→2-Ethoxy-1-methyl-4-nitrobenzene→1-(Bromomethyl)-2-ethoxy-4-nitrobenzene→1-(Bromomethyl)-5-chloro-2-ethoxy-4-nitrobenzene→1-Chloro-4-ethoxy-5-(methoxymethyl)-2-nitrobenzene→2-Chloro-5-ethoxy-4-(methoxymethyl)aniline→[4-(4-Fluorobenzyl)-2-morpholinyl]methylamine→Mosapride Citrate-007

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