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CAS 1186422-36-5
N-[(1E,4S)-4-(3,4-Dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-ylidene]methanamine
Codes：Sertraline Hydrochloride-093
Application context (from source-drug indications)
强迫性障碍枸橼酸舍曲林
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 枸橼酸舍曲林Sertraline Citrate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Benzaldehyde→Allyl(bromo)magnesium→1-Phenylbut-3-en-1-ol→(1S)-1-Phenylbut-3-en-1-ol→N,N-Diisopropylcarbamic chloride→(1S)-1-Phenylbut-3-en-1-yl dipropan-2-ylcarbamate→2-(3,4-Dichlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane→(3,4-Dichlorophenyl)boronic acid→2,3-Dimethyl-2,3-butanediol→2-[(1R)-1-(3,4-Dichlorophenyl)-1-phenylbut-3-en-1-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane→1,2-Dichloro-4-[(1R)-1-phenylbut-3-en-1-yl]benzene→(4R)-4-(3,4-Dichlorophenyl)-4-phenylbutanoic acid→4(S)-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-one→N-Methylhydroxylamine→N-[(1E,4S)-4-(3,4-Dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-ylidene]methanamine→(1S,4S)-4-(3,4-Dichlorophenyl)-N-methyltetralin-1-amine
4-(3,4-Dichlorophenyl)-1-tetralone→(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-ol→4(S)-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-one→Aminomethane→N-[(1E,4S)-4-(3,4-Dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-ylidene]methanamine→(1S,4S)-4-(3,4-Dichlorophenyl)-N-methyltetralin-1-amine→[5,5'-Biquinoline]-6,6'-diol→Sertraline Hydrochloride-157
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