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CAS 1205676-33-0
(3aS,6aR)-1,3a,4,5,6,6a-hexahydrocyclopenta[c]pyrrole
Codes：TELAP-034
Application context (from source-drug indications)
丙型肝炎特拉匹韦慢性丙型肝炎特拉匹韦HIV感染特拉匹韦肝功能衰退特拉匹韦阿片类依赖特拉匹韦肾脏疾病特拉匹韦
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 特拉匹韦Telaprevir | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
pyrazine-2-carboxylic acid→methyl (S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoate→(S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoic acid→(S)-2-aminopentan-1-ol→(S)-N-(1-hydroxypentan-2-yl)formamide→(S)-N-(1-oxopentan-2-yl)formamide→isocyanocyclopropane→(3S)-1-(cyclopropylamino)-3-formamido-1-oxohexan-2-yl acetate→(3S)-1-(cyclopropylamino)-3-isocyano-1-oxohexan-2-yl acetate→(3aS,6aR)-1,3a,4,5,6,6a-hexahydrocyclopenta[c]pyrrole→(3S)-3-((1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxamido)-1-(cyclopropylamino)-1-oxohexan-2-yl acetate→methyl (S)-2-amino-2-cyclohexylacetate→methyl (S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetate→(S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetic acid→methyl (S)-2-amino-3,3-dimethylbutanoate
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