CAS 122-00-9

1-(p-tolyl)ethan-1-one

Codes: CELE-001

Application context (from source-drug indications)

PainCelecoxibInflammatory diseaseCelecoxib关节周围炎Celecoxib肌腱炎Celecoxib颈肩腕综合征CelecoxibLow back painCelecoxib

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Celecoxib	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

CelecoxibOriginator routesteps: 2total yield: /

1-(p-tolyl)ethan-1-one→ethyl 2,2,2-trifluoroacetate→4,4,4-trifluoro-1-(p-tolyl)butane-1,3-dione→4-hydrazinylbenzenesulfonamide hydrochloride

CelecoxibOptimised routesteps: 4total yield: 8.7 g

1-(p-tolyl)ethan-1-one→4-hydrazinylbenzenesulfonamide hydrochloride→4-(2-(2,2,2-trifluoroacetyl)hydrazinyl)benzenesulfonamide→(Z)-benzenesulfonic (Z)-2,2,2-trifluoro-N-(4-sulfamoylphenyl)acetohydrazonic anhydride→4-(1-(p-tolyl)vinyl)morpholine→morpholine

Intermediates available on this site

No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.