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CAS 122263-03-0
2-(2,4-difluorophenyl)-2-oxoethyl acetate
Codes：POSA-002
Application context (from source-drug indications)
念珠菌病泊沙康唑曲霉菌属感染泊沙康唑真菌感染泊沙康唑口腔念珠菌病泊沙康唑球孢菌病泊沙康唑组织胞浆菌病泊沙康唑
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 泊沙康唑Posaconazole | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(R)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propane-1,2-diol→(R)-2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl methanesulfonate→(R)-1-((2-(2,4-difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole→diethyl malonate→ethyl (5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)-2-oxotetrahydrofuran-3-carboxylate→(R)-4-(2,4-difluorophenyl)-2-(hydroxymethyl)-5-(1H-1,2,4-triazol-1-yl)pentane-1,4-diol→(R)-2-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)propane-1,3-diyl bis(4-methylbenzenesulfonate)→((3S,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate→4-(4-(4-nitrophenyl)piperazin-1-yl)phenol→1-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)-4-(4-nitrophenyl)piperazine→4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)aniline→phenyl carbonochloridate→phenyl (4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)carbamate→N-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)hydrazinecarboxamide→4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one→(2S,3R)-2-((benzyloxy)methoxy)pentan-3-yl 4-bromobenzenesulfonate→2-chloro-1-(2,4-difluorophenyl)ethan-1-one→2-(2,4-difluorophenyl)-2-oxoethyl acetate→2-(2,4-difluorophenyl)allyl acetate→2-(2,4-difluorophenyl)prop-2-en-1-ol→(S)-(2-(2,4-difluorophenyl)oxiran-2-yl)methanol→1H-1,2,4-triazole
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