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CAS 1226781-80-1
2-(Methanesulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole
Codes: (IV)908111-1-a
Application context (from source-drug indications)
Type 2 diabetesCofrogliptin葡糖耐受不良CofrogliptinRenal impairmentCofrogliptin
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Cofrogliptin | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
tert-Butyl 2,6-dihydropyrrolo[3,4-c]pyrazole-5(4H)-carboxylate→Chloro methyl sulfone→tert-Butyl 2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazole-5(4H)-carboxylate→2-(Methanesulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole→tert-Butyl [(2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl]carbamate→(2xi,6R)-2,6-Anhydro-5-[(tert-butoxycarbonyl)amino]-1,4,5-trideoxy-6-(2,5-difluorophenyl)-1,1,1-trifluoro-D-glycero-hex-3-ulose→(6R)-2,6-Anhydro-5-[(tert-butoxycarbonyl)amino]-1,3,4,5-tetradeoxy-6-(2,5-difluorophenyl)-1,1,1-trifluoro-3-[2-(methanesulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-D-threo-hex-3-enitol→(6R)-2,6-Anhydro-5-[(tert-butoxycarbonyl)amino]-1,3,4,5-tetradeoxy-6-(2,5-difluorophenyl)-1,1,1-trifluoro-3-[2-(methanesulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-D-arabino-hexitol
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