CAS 123-62-6

propionic anhydride

Codes: PARE-005

Application context (from source-drug indications)

Postoperative painParecoxib Sodium神经疾病Parecoxib Sodium肩部疼痛Parecoxib Sodium

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Parecoxib Sodium	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Parecoxib SodiumOriginator routesteps: 5total yield: 12.2 g

1,2-diphenylethan-1-one→(E)-1,2-diphenylethan-1-one oxime→5-methyl-3,4-diphenyl-4,5-dihydroisoxazol-5-ol→4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide→propionic anhydride→N-((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)propionamide

Parecoxib SodiumOptimised routesteps: 7total yield: 9.11 g

1,2-diphenylethan-1-one→5-methyl-3,4-diphenyl-4,5-dihydroisoxazol-5-ol→4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide→propionic anhydride→N-((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)propionamide→(Z)-1-(1,2-diphenylvinyl)pyrrolidine→(Z)-3,4-diphenyl-4-(pyrrolidin-1-yl)but-3-en-2-one→5-methyl-3,4-diphenylisoxazole

Parecoxib SodiumOptimised routesteps: 5total yield: 11.9 g

1,2-diphenylethan-1-one→4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide→propionic anhydride→4-(2-oxo-2-phenylethyl)benzenesulfonic acid→4-(1,3-dioxo-1-phenylbutan-2-yl)benzenesulfonic acid→4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonic acid

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Unibest Nantong cGMP Site	5-Methyl-3,4-diphenylisoxazole Pharmaceutical Intermediates	On request	On request	On request	—

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