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CAS 1269440-49-4
1-(3-iodo-1-isopropyl-1H-pyrazol-4-yl)ethan-1-one
Codes：ENCO-008
Application context (from source-drug indications)
非小细胞肺癌恩考芬尼结直肠癌恩考芬尼甲状腺瘤恩考芬尼黑色素瘤恩考芬尼
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 恩考芬尼Encorafenib | Tier C — Watch / trade | 2030 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
benzaldehyde→isopropylhydrazine hydrochloride→(E)-1-benzylidene-2-isopropylhydrazine→2-(ethoxymethylene)malononitrile→(E)-2-((2-benzylidene-1-isopropylhydrazinyl)methylene)malononitrile→3-amino-1-isopropyl-1H-pyrazole-4-carbonitrile→1-(3-amino-1-isopropyl-1H-pyrazol-4-yl)ethan-1-one→1-(3-iodo-1-isopropyl-1H-pyrazol-4-yl)ethan-1-one→(Z)-3-(dimethylamino)-1-(3-iodo-1-isopropyl-1H-pyrazol-4-yl)prop-2-en-1-one→guanidine hydrochloride→4-(3-iodo-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-amine→4-(3-iodo-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ol→2-chloro-4-(3-iodo-1-isopropyl-1H-pyrazol-4-yl)pyrimidine→methyl (S)-(1-aminopropan-2-yl)carbamate hydrochloride→methyl (S)-(1-((4-(3-iodo-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate→tert-butyl (5-chloro-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate→methyl (S)-(1-((4-(3-(3-((tert-butoxycarbonyl)amino)-5-chloro-2-fluorophenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate→methyl (S)-(1-((4-(3-(3-amino-5-chloro-2-fluorophenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate→methyl (S)-(1-((4-(3-(5-chloro-2-fluoro-3-(N-(methylsulfonyl)methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate→2-bromo-4-chloro-1-fluorobenzene→3-bromo-5-chloro-2-fluorobenzoic acid→tert-butyl (3-bromo-5-chloro-2-fluorophenyl)carbamate→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)
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