CAS 127641-25-2

(1R,2S)-1-phenyl-2-(pyrrolidin-1-yl)propan-1-ol

Codes：EFAV-012

Application context (from source-drug indications)

HIV感染依非韦伦/拉米夫定/富马酸替诺福韦二吡呋酯

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
依非韦伦/拉米夫定/富马酸替诺福韦二吡呋酯Efavirenz/Lamivudine/Tenofovir Disoproxil Fumarate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

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依非韦伦/拉米夫定/富马酸替诺福韦二吡呋酯优化路线steps: 5total yield: /

N-(4-chlorophenyl)pivalamide→1-(2-amino-5-chlorophenyl)-2,2,2-trifluoroethanone→ethynylcyclopropane→1-(chloromethyl)-4-methoxybenzene→1-(5-chloro-2-((4-methoxybenzyl)amino)phenyl)-2,2,2-trifluoroethanone→(1R,2S)-1-phenyl-2-(pyrrolidin-1-yl)propan-1-ol→(S)-2-(5-chloro-2-((4-methoxybenzyl)amino)phenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol→(S)-6-chloro-4-(cyclopropylethynyl)-1-(4-methoxybenzyl)-4-(trifluoromethyl)-1H-benzo[d][1,3]oxazin-2(4H)-one

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