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CAS 1309115-67-0
3-ethyl 5-methyl 2-(bromomethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Codes：(VI)109067-9-a
Application context (from source-drug indications)
高血压Olmesartan Medoxomil/Amlodipine orotate原发性高血压缬沙坦/氨氯地平乳清酸盐
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Olmesartan Medoxomil/Amlodipine orotateOlmesartan Medoxomil/Amlodipine orotate | Tier C — Watch / trade | - |
| 缬沙坦/氨氯地平乳清酸盐Valsartan/Amlodipine Orotate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-Butynoic acid methyl ester→1-Phenylmethylamine→ethyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate→3-methyl 5-propyl 1-benzyl-4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 2-(bromomethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→2-azidoethan-1-ol→3-methyl 5-propyl 6-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-2-methyl-1,4-dihydropyridine-3,5-dicarboxylate
2-Butynoic acid methyl ester→1-Phenylmethylamine→ethyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate→3-methyl 5-propyl 1-benzyl-4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 2-(bromomethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→2-azidoethan-1-ol→3-methyl 5-propyl 6-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-2-methyl-1,4-dihydropyridine-3,5-dicarboxylate
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