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CAS 1309767-90-5

5-((1R,4R)-4-((tert-butoxycarbonyl)oxy)cyclopent-2-en-1-yl)-2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl acetate

Codes: ABAC-025

Application context (from source-drug indications)

HIV infectionAbacavir Sulfate艾滋病痴呆综合征Abacavir Sulfate

Source drugs (routes using this intermediate)

DrugTierExpiry
Abacavir SulfateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Abacavir SulfateOptimised routesteps: 4total yield: /
2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl acetate→di-tert-butyl (1R,3S)-cyclopent-4-ene-1,3-diyl dicarbonate→5-((1R,4R)-4-((tert-butoxycarbonyl)oxy)cyclopent-2-en-1-yl)-2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl acetate→5-((1R,4R)-4-azidocyclopent-2-en-1-yl)-2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl acetate→(1S,4R)-methyl 4-azidocyclopent-2-enecarboxylate→((1S,4R)-4-acetamidocyclopent-2-en-1-yl)methyl acetate

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