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CAS 1312954-53-2
4-(2-bromo-5-fluorobenzyl)-6-methyl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one
Codes: FOTAG-005
Application context (from source-drug indications)
Type 2 diabetesFultagliptin BenzoateRenal impairmentFultagliptin Benzoate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Fultagliptin Benzoate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-bromo-2-(bromomethyl)-4-fluorobenzene→1-bromo-4-fluoro-2-(isothiocyanatomethyl)benzene→N-(2-bromo-5-fluorobenzyl)hydrazinecarbothioamide→(Z)-methyl 2-(2-((2-bromo-5-fluorobenzyl)carbamothioyl)hydrazono)propanoate→4-(2-bromo-5-fluorobenzyl)-6-methyl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one→4-(2-bromo-5-fluorobenzyl)-6-methyl-3-(methylthio)-1,2,4-triazin-5(4H)-one→(R)-tert-butyl piperidin-3-ylcarbamate→(R)-tert-butyl (1-(4-(2-bromo-5-fluorobenzyl)-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)piperidin-3-yl)carbamate→(R)-tert-butyl (1-(4-(2-cyano-5-fluorobenzyl)-6-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-3-yl)piperidin-3-yl)carbamate→(R)-2-((3-(3-aminopiperidin-1-yl)-6-methyl-5-oxo-1,2,4-triazin-4(5H)-yl)methyl)-4-fluorobenzonitrile→Fotagliptin Benzoate
Intermediates available on this site
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