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CAS 132245-51-3

(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl cyclopropanecarboxylate

Codes:DEXA-003

Application context (from source-drug indications)

过敏性鼻炎地塞米松培酯季节性过敏性鼻炎地塞米松培酯多发性骨髓瘤地塞米松培酯前体T-淋巴母细胞性淋巴瘤白血病地塞米松培酯肝癌地塞米松培酯实体瘤地塞米松培酯

Source drugs (routes using this intermediate)

DrugTierExpiry
地塞米松培酯Dexamethasone CipecilateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

地塞米松培酯原研路线steps: 2total yield: /
(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one→(trimethoxymethyl)cyclopropane→(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl cyclopropanecarboxylate→cyclohexanecarbonyl chloride

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