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CAS 132748-10-8
3(R),5(R)-Dihydroxy-7-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid
Codes：(I)122234-12-a、(IV)122234-14-a
Application context (from source-drug indications)
血脂障碍非诺贝特/辛伐他汀高脂血症非诺贝特/辛伐他汀心脏和血管疾病非诺贝特/辛伐他汀高胆固醇血症非诺贝特/辛伐他汀
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 非诺贝特/辛伐他汀Fenofibrate/Simvastatin | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3(R),5(R)-Dihydroxy-7-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid→4(R)-Hydroxy-6(R)-[2-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalenyl]ethyl]tetrahydropyran-2-one→2,2-Dimethylbutanoyl chloride
2,2-Dimethylbutanoyl chloride→S-(2-Hydroxyethyl) 2,2-dimethylbutanethioate→2-[(2,2-Dimethylbutanoyl)sulfanyl]ethyl acetate→3(R),5(R)-Dihydroxy-7-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid→(betaR,deltaR,1S,2S,6R,8S,8aR)-8-(2,2-Dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoic acid ammonium salt
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