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CAS 1333313-44-2
N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-4-(1,3-dioxoisoindolin-2-yl)-N-isobutylbenzenesulfonamide hydrochloride
Codes: FOSAC-020
Application context (from source-drug indications)
HIV infectionFosamprenavir Calcium
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Fosamprenavir Calcium | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
tert-butyl ((2S,3R)-3-hydroxy-4-(isobutylamino)-1-phenylbutan-2-yl)carbamate→tert-butyl ((S)-1-((S)-oxiran-2-yl)-2-phenylethyl)carbamate→(S)-tetrahydrofuran-3-yl 1H-imidazole-1-carboxylate→(S)-tetrahydrofuran-3-yl ((2S,3R)-4-((4-amino-N-isobutylphenyl)sulfonamido)-1-phenyl-3-(phosphonooxy)butan-2-yl)carbamate→4-(1,3-dioxoisoindolin-2-yl)benzenesulfonyl chloride→N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-4-(1,3-dioxoisoindolin-2-yl)-N-isobutylbenzenesulfonamide hydrochloride→(S)-tetrahydrofuran-3-yl ((2S,3R)-4-((4-(1,3-dioxoisoindolin-2-yl)-N-isobutylphenyl)sulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate→(S)-tetrahydrofuran-3-yl ((2S,3R)-4-((4-(1,3-dioxoisoindolin-2-yl)-N-isobutylphenyl)sulfonamido)-1-phenyl-3-(phosphonooxy)butan-2-yl)carbamate
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