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CAS 1350636-89-3
S-((1R,2R,4R)-4-((tert-butoxycarbonyl)amino)-2-hydroxycyclohexyl) benzothioate
Codes：LEFA-012
Application context (from source-drug indications)
感染来法莫林社区获得性感染来法莫林细菌性肺炎来法莫林肺炎来法莫林社区获得性肺炎来法莫林囊性纤维化来法莫林
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 来法莫林Lefamulin | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(3aR,4R,5R,7S,8S,9R,9aS,12R)-8-hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-(((1R,2R,4R)-4-((tert-butoxycarbonyl)amino)-2-hydroxycyclohexyl)thio)acetate→cyclohex-3-ene-1-carboxylic acid→(S)-1-phenylethan-1-amine→(S)-1-phenylethan-1-aminium (R)-cyclohex-3-ene-1-carboxylate→(R)-cyclohex-3-ene-1-carboxylic acid→tert-butyl (R)-cyclohex-3-en-1-ylcarbamate→tert-butyl ((1R,3R,6S)-7-oxabicyclo[4.1.0]heptan-3-yl)carbamate→S-((1R,2R,4R)-4-((tert-butoxycarbonyl)amino)-2-hydroxycyclohexyl) benzothioate→tert-butyl ((1R,3R,4R)-3-hydroxy-4-mercaptocyclohexyl)carbamate→(3aR,4R,5R,7S,8S,9R,9aS,12R)-8-hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-(tosyloxy)acetate
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