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CAS 1355357-49-1
(2R,3R,4R,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-carbonitrile
Codes: (I)1140100-1-a
Application context (from source-drug indications)
COVID-19Deuremidevir hydrobromide呼吸道合胞体病毒感染Deuremidevir hydrobromide亨尼波病毒属感染Deuremidevir hydrobromide
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Deuremidevir hydrobromide | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(2R,3R,4R,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-carbonitrile→(2R,3R,4R,5R)-2-(4-Amino-5-iodopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-bis(benzyloxy)-5-[(benzyloxy)methyl]oxolane-2-carbonitrile→(2R,3R,4R,5R)-2-[4-Amino-5-deuteropyrrolo[2,1-f][1,2,4]triazin-7-yl]-3,4-bis(benzyloxy)-5-[(benzyloxy)methyl]oxolane-2-carbonitrile→(2R,3R,4S,5R)-2-(4-Amino-5-deuteriopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile→N'-[7-[(2R,3R,4S,5R)-2-Cyano-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-deuteropyrrolo[2,1-f][1,2,4]triazin-4-yl]-N,N-dimethylmethanimidamide→2-Methylpropanoyl chloride→2-Methylpropanoyl 2-methylpropanoate→(2R,3R,4R,5R)-2-Cyano-2-[4-[(Z)-[(dimethylamino)methylidene]amino]-5-deuteropyrrolo[2,1-f][1,2,4]triazin-7-yl]-5-[[(2-methylpropanoyl)oxy]methyl]oxolane-3,4-diyl bis(2-methylpropanoate)→(2R,3R,4R,5R)-2-[4-Amino-5-deuteropyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-cyano-5-[[(2-methylpropanoyl)oxy]methyl]oxolane-3,4-diyl bis(2-methylpropanoate)
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