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CAS 137973-76-3
N-(4-(7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide
Codes：TOLV-006
Application context (from source-drug indications)
常染色体显性多囊肾病托伐普坦纤维化托伐普坦低钠血症托伐普坦心脏衰竭托伐普坦抗利尿激素分泌失调综合征托伐普坦
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 托伐普坦Tolvaptan | Tier B — Position early | 2028 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one→3-methyl-4-nitrobenzoyl chloride→7-chloro-1-(2-methyl-4-nitrobenzoyl)-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one→1-(4-amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one→2-methylbenzoyl chloride→N-(4-(7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide
7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one→N-(4-(7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide→N-(4-bromo-3-methylphenyl)-2-methylbenzamide
7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one→3-methyl-4-nitrobenzoyl chloride→7-chloro-1-(2-methyl-4-nitrobenzoyl)-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one→1-(4-amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one→2-methylbenzoyl chloride→N-(4-(7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide
7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one→3-methyl-4-nitrobenzoyl chloride→7-chloro-1-(2-methyl-4-nitrobenzoyl)-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one→1-(4-amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one→2-methylbenzoyl chloride→N-(4-(7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide→5-chloro-2-fluorobenzaldehyde→diallylamine→5-chloro-2-(diallylamino)benzaldehyde→1-allyl-7-chloro-2,3,4,5-tetrahydro-1H-2,5-epoxybenzo[b]azepine→1-allyl-7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one→3-methyl-4-nitrobenzoyl chloride→7-chloro-1-(2-methyl-4-nitrobenzoyl)-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one→1-(4-amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one→2-methylbenzoyl chloride→N-(4-(7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide→5-chloro-2-nitrobenzoic acid→methyl 5-chloro-2-nitrobenzoate→methyl 2-amino-5-chlorobenzoate→methyl 5-chloro-2-((4-methylphenyl)sulfonamido)benzoate→ethyl 4-bromobutanoate→methyl 5-chloro-2-((N-(4-ethoxy-4-oxobutyl)-4-methylphenyl)sulfonamido)benzoate→methyl 7-chloro-5-oxo-1-tosyl-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carboxylate→7-chloro-1-tosyl-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
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