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CAS 1384863-95-9

4-([2-[(Propan-2-yl)oxy]ethoxy]methyl)phenyl methanesulfonate

Codes:Bisoprolol-026

Application context (from source-drug indications)

高血压苯磺酸氨氯地平/富马酸比索洛尔原发性高血压苯磺酸氨氯地平/富马酸比索洛尔

Source drugs (routes using this intermediate)

DrugTierExpiry
苯磺酸氨氯地平/富马酸比索洛尔Amlodipine Besylate/Bisoprolol FumarateTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

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苯磺酸氨氯地平/富马酸比索洛尔优化路线steps: 4total yield: 5.57g(Bisoprolol-030)
4-([2-[(Propan-2-yl)oxy]ethoxy]methyl)phenyl methanesulfonate→(R)-Glycidol→(2S)-2-[[4-([2-[(Propan-2-yl)oxy]ethoxy]methyl)phenoxy]methyl]oxirane→(-)-1-[4-(2-Isopropoxyethoxymethyl)phenoxy]-3-(isopropylamino)-2(S)-propanol→But-2-enedioic acid (2S)-1-[(propan-2-yl)amino]-3-[4-([2-[(propan-2-yl)oxy]ethoxy]methyl)phenoxy]propan-2-ol→4-[(2-Isopropoxyethoxy)methyl]phenol→Monoisopropylamine

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