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CAS 139481-41-7

ethyl 1-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

Codes:AZILS-009

Application context (from source-drug indications)

高血压阿齐沙坦原发性高血压阿齐沙坦二型糖尿病阿齐沙坦肥胖症阿齐沙坦糖尿病阿齐沙坦

Source drugs (routes using this intermediate)

DrugTierExpiry
阿齐沙坦AzilsartanTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

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阿齐沙坦优化路线steps: 3total yield: 173.2 g
methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate→ethyl 1-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate→2,6-dichloro-9-((3S,4R,5R)-3-fluoro-4-((triisopropylsilyl)oxy)-5-(((triisopropylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-9H-purine

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