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CAS 1411634-44-0
Methyl (Z)-N-[[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methylidene]-L-alaninate
Codes：Enalapril-036
Application context (from source-drug indications)
心脏和血管疾病阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利高血压阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利高脂血症阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利心脏病阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利原发性高血压马来酸依那普利/叶酸
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利Atorvastatin/Hydrochlorothiazide/Aspirin/Enalapril | Tier C — Watch / trade | - |
| 马来酸依那普利/叶酸Enalapril Maleate/Folic Acid | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2,2-Dimethyl-1,3-dioxolane-4(R)-carbaldehyde→L-Alanine methyl ester→Methyl (Z)-N-[[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methylidene]-L-alaninate→Benzyloxyacetyl chloride→Triphenyl(phenylmethyl)phosphonium chloride→Methyl (2S)-2-[(2S,3R)-3-(benzyloxy)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-4-oxoazetidin-1-yl]propanoate→Methyl (2S)-2-[(2S,3R)-3-(benzyloxy)-2-[(1S)-1,2-dihydroxyethyl]-4-oxoazetidin-1-yl]propanoate→Methyl (2S)-2-[(2R,3R)-3-(benzyloxy)-2-formyl-4-oxoazetidin-1-yl]propanoate→Benzylidene(triphenyl)-lambda5-phosphane→Methyl (2S)-2-[(3R,4S)-3-(benzyloxy)-2-oxo-4-[(E)-2-phenylethenyl]azetidin-1-yl]propanoate→(2S)-2-[(3R,4S)-3-Hydroxy-2-oxo-4-(2-phenylethyl)azetidin-1-yl]propanoic acid→Benzyl L-prolinate→Benzyl 1-[(2S)-2-[(3R,4S)-3-hydroxy-2-oxo-4-(2-phenylethyl)azetidin-1-yl]propanoyl]-L-prolinate→Benzyl 1-[(2S)-2-[(4S)-2,5-dioxo-4-(2-phenylethyl)-1,3-oxazolidin-3-yl]propanoyl]-L-prolinate→Ethyl alcohol→(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline
2,2-Dimethyl-1,3-dioxolane-4(R)-carbaldehyde→L-Alanine methyl ester→Methyl (Z)-N-[[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methylidene]-L-alaninate→Benzyloxyacetyl chloride→Triphenyl(phenylmethyl)phosphonium chloride→Methyl (2S)-2-[(2S,3R)-3-(benzyloxy)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-4-oxoazetidin-1-yl]propanoate→Methyl (2S)-2-[(2S,3R)-3-(benzyloxy)-2-[(1S)-1,2-dihydroxyethyl]-4-oxoazetidin-1-yl]propanoate→Methyl (2S)-2-[(2R,3R)-3-(benzyloxy)-2-formyl-4-oxoazetidin-1-yl]propanoate→Benzylidene(triphenyl)-lambda5-phosphane→Methyl (2S)-2-[(3R,4S)-3-(benzyloxy)-2-oxo-4-[(E)-2-phenylethenyl]azetidin-1-yl]propanoate→(2S)-2-[(3R,4S)-3-Hydroxy-2-oxo-4-(2-phenylethyl)azetidin-1-yl]propanoic acid→Benzyl L-prolinate→Benzyl 1-[(2S)-2-[(3R,4S)-3-hydroxy-2-oxo-4-(2-phenylethyl)azetidin-1-yl]propanoyl]-L-prolinate→Benzyl 1-[(2S)-2-[(4S)-2,5-dioxo-4-(2-phenylethyl)-1,3-oxazolidin-3-yl]propanoyl]-L-prolinate→Ethyl alcohol→(S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline
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