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CAS 142148-14-9
methyl 2-(1-((acetylthio)methyl)cyclopropyl)acetate
Codes: MONT-011
Application context (from source-drug indications)
Allergic rhinitisMontelukastAsthmaMontelukastHypersensitivity reactionMontelukastSeasonal allergic rhinitisMontelukastPerennial allergic rhinitisMontelukastExercise-induced asthmaMontelukast
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Montelukast | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
7-chloro-2-methylquinoline→isophthalaldehyde→(E)-3-(2-(7-chloroquinolin-2-yl)vinyl)benzaldehyde→(E)-1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)prop-2-en-1-ol→methyl 2-bromobenzoate→methyl (E)-2-(3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-oxopropyl)benzoate→methyl (S,E)-2-(3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-hydroxypropyl)benzoate→(S,E)-1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propan-1-ol→(1S)-1-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-((tetrahydro-2H-pyran-2-yl)oxy)propan-2-yl)phenyl)propan-1-ol→(1S)-1-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-((tetrahydro-2H-pyran-2-yl)oxy)propan-2-yl)phenyl)propyl methanesulfonate→methyl 2-(1-((acetylthio)methyl)cyclopropyl)acetate→methyl 2-(1-((((1R)-1-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-((tetrahydro-2H-pyran-2-yl)oxy)propan-2-yl)phenyl)propyl)thio)methyl)cyclopropyl)acetate→pyridine→(R,E)-2-(1-(((1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propyl)thio)methyl)cyclopropyl)acetic acid→diethyl cyclopropane-1,1-dicarboxylate→cyclopropane-1,1-diyldimethanol→(1-(hydroxymethyl)cyclopropyl)methyl benzoate→(1-(cyanomethyl)cyclopropyl)methyl benzoate→2-(1-(hydroxymethyl)cyclopropyl)acetic acid
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