← Back to patent-cliff list
CAS 1446094-54-7
(3S,4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a-hydroxy-3-methyl-7-oxo-9-((2-(trimethylsilyl)ethoxy)methoxy)-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-3-ium iodide
Codes：METHB-013
Application context (from source-drug indications)
阿片类依赖溴化甲基纳曲酮便秘溴化甲基纳曲酮阿片类药物引起的便秘溴化甲基纳曲酮慢性疼痛溴化甲基纳曲酮胰腺癌溴化甲基纳曲酮肠阻塞症溴化甲基纳曲酮
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 溴化甲基纳曲酮Methylnaltrexone Bromide | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one→(4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a-hydroxy-9-((2-(trimethylsilyl)ethoxy)methoxy)-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one→(3S,4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a-hydroxy-3-methyl-7-oxo-9-((2-(trimethylsilyl)ethoxy)methoxy)-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-3-ium iodide
Intermediates available on this site
No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.