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CAS 144967-77-1
(Z)-but-2-ene-1,4-diyl dibutyrate
Codes：EMTR-002
Application context (from source-drug indications)
HIV感染比克恩丙诺乙型肝炎比克恩丙诺HIV感染恩曲他滨/富马酸磷丙替诺福韦获得性免疫缺损综合征恩曲他滨/富马酸磷丙替诺福韦进行性多病灶脑白质病恩曲他滨/富马酸磷丙替诺福韦HIV感染恩曲他滨/盐酸利匹韦林/富马酸替诺福韦二吡呋酯
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 比克恩丙诺Bictegravir/Emtricitabine/Tenofovir Alafenamide Fumarate | Tier B — Position early | - |
| 恩曲他滨/富马酸磷丙替诺福韦Emtricitabine/Tenofovir Alafenamide Fumarate | Tier B — Position early | - |
| 恩曲他滨/盐酸利匹韦林/富马酸替诺福韦二吡呋酯Emtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil Fumarate | Tier B — Position early | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(Z)-but-2-ene-1,4-diol→(Z)-but-2-ene-1,4-diyl dibutyrate→2-oxoethyl butyrate→2-mercaptoacetic acid→(5-oxo-1,3-oxathiolan-2-yl)methyl butyrate→(5-acetoxy-1,3-oxathiolan-2-yl)methyl butyrate→5-fluoro-N-(trimethylsilyl)-2-((trimethylsilyl)oxy)pyrimidin-4-amine→(5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl butyrate→((2R,5S)-5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl butyrate
(Z)-but-2-ene-1,4-diol→(Z)-but-2-ene-1,4-diyl dibutyrate→2-oxoethyl butyrate→2-mercaptoacetic acid→(5-oxo-1,3-oxathiolan-2-yl)methyl butyrate→(5-acetoxy-1,3-oxathiolan-2-yl)methyl butyrate→5-fluoro-N-(trimethylsilyl)-2-((trimethylsilyl)oxy)pyrimidin-4-amine→(5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl butyrate→((2R,5S)-5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl butyrate
(Z)-but-2-ene-1,4-diol→(Z)-but-2-ene-1,4-diyl dibutyrate→2-oxoethyl butyrate→2-mercaptoacetic acid→(5-oxo-1,3-oxathiolan-2-yl)methyl butyrate→(5-acetoxy-1,3-oxathiolan-2-yl)methyl butyrate→5-fluoro-N-(trimethylsilyl)-2-((trimethylsilyl)oxy)pyrimidin-4-amine→(5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl butyrate→((2R,5S)-5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl butyrate
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