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CAS 147189-93-3
(5R)-5-(3,4-Dichlorophenyl)oxolan-2-one2(3H)-Furanone, 5-(3,4-dichlorophenyl)dihydro-, (5R)-
Codes：Sertraline Hydrochloride-095
Application context (from source-drug indications)
强迫性障碍枸橼酸舍曲林
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 枸橼酸舍曲林Sertraline Citrate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-(3,4-Dichlorophenyl)-4-oxobutanoic acid→4-(3,4-Dichlorophenyl)-4-hydroxybutanoic acid→(5R)-5-(3,4-Dichlorophenyl)oxolan-2-one→(1R)-1-(3,4-Dichlorophenyl)butane-1,4-diol→(1R)-1-(3,4-Dichlorophenyl)-4-[[(2,3,3-trimethylbutan-2-yl)silyl]oxy]butan-1-ol→(4R)-4-(3,4-Dichlorophenyl)-4-phenylbutanoic acid→(1R)-1-(3,4-Dichlorophenyl)-4-[[(2,3,3-trimethylbutan-2-yl)silyl]oxy]butyl methanesulfonate→Phenyllithium→[(4R)-4-(3,4-Dichlorophenyl)-4-phenylbutoxy](2,3,3-trimethylbutan-2-yl)silane→(4R)-4-(3,4-Dichlorophenyl)-4-phenylbutan-1-ol
(5R)-5-(3,4-Dichlorophenyl)oxolan-2-one→1,2-Dichlorobenzene→2-Chloranylethanoyl chloride→2-Chloro-1-(3,4-dichlorophenyl)ethan-1-one→(1S)-2-Chloro-1-(3,4-dichlorophenyl)ethan-1-ol→(2S)-2-(3,4-Dichlorophenyl)oxirane→Carbethoxyacetic ester
4-(3,4-Dichlorophenyl)-4-oxobutanoic acid→2(3H)-Furanone, 5-(3,4-dichlorophenyl)dihydro-, (5R)-→(4R)-4-(3,4-Dichlorophenyl)-4-hydroxybutanoic acid
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