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CAS 147403-95-0

3-(4'-(bromomethyl)-[1,1'-biphenyl]-2-yl)-5-(trichloromethyl)-1,2,4-oxadiazole

Codes:AZIL-026

Application context (from source-drug indications)

高血压阿齐沙坦酯钾盐/氯噻酮原发性高血压阿齐沙坦酯钾盐/氯噻酮

Source drugs (routes using this intermediate)

DrugTierExpiry
阿齐沙坦酯钾盐/氯噻酮Azilsartan Medoxomil Potassium/ChlorthalidoneTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

阿齐沙坦酯钾盐/氯噻酮优化路线steps: 5total yield: /
4'-methyl-[1,1'-biphenyl]-2-carbonitrile→N'-hydroxy-4'-methyl-[1,1'-biphenyl]-2-carboximidamide→3-(4'-methyl-[1,1'-biphenyl]-2-yl)-5-(trichloromethyl)-1,2,4-oxadiazole→3-(4'-(bromomethyl)-[1,1'-biphenyl]-2-yl)-5-(trichloromethyl)-1,2,4-oxadiazole→methyl 2-ethoxy-1H-benzo[d]imidazole-7-carboxylate→2,6-dichloro-9-((3S,4R,5R)-3-fluoro-4-((triisopropylsilyl)oxy)-5-(((triisopropylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-9H-purine

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