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CAS 152628-01-8
methyl 4-butyramido-3-methyl-5-nitrobenzoate
Codes：TELM-004
Application context (from source-drug indications)
高血压替米沙坦/苯磺酸氨氯地平/氢氯噻嗪高血压瑞舒伐他汀钙/替米沙坦高脂血症瑞舒伐他汀钙/替米沙坦高血压苯磺酸氨氯地平/替米沙坦
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 替米沙坦/苯磺酸氨氯地平/氢氯噻嗪Telmisartan/Amlodipine Besylate/Hydrochlorothiazide | Tier C — Watch / trade | - |
| 瑞舒伐他汀钙/替米沙坦Rosuvastatin Calcium/Telmisartan | Tier C — Watch / trade | - |
| 苯磺酸氨氯地平/替米沙坦Amlodipine Besylate/Telmisartan | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
methyl 4-amino-3-methylbenzoate→butyryl chloride→methyl 4-butyramido-3-methylbenzoate→methyl 4-butyramido-3-methyl-5-nitrobenzoate→methyl 3-amino-4-butyramido-5-methylbenzoate→methyl 4-methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylate→4-methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylic acid→TELM-008→1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole→tert-butyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate→tert-butyl 4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylate
methyl 4-amino-3-methylbenzoate→butyryl chloride→methyl 4-butyramido-3-methylbenzoate→methyl 4-butyramido-3-methyl-5-nitrobenzoate→methyl 3-amino-4-butyramido-5-methylbenzoate→methyl 4-methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylate→4-methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylic acid→TELM-008→1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole→tert-butyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate→tert-butyl 4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylate
methyl 4-amino-3-methylbenzoate→butyryl chloride→methyl 4-butyramido-3-methylbenzoate→methyl 4-butyramido-3-methyl-5-nitrobenzoate→methyl 3-amino-4-butyramido-5-methylbenzoate→methyl 4-methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylate→4-methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylic acid→TELM-008→1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole→tert-butyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate→tert-butyl 4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carboxylate
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