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CAS 153145-22-3
methyl 3-[(1S,5S,6R,9S,10S,12R,15S)-15-[(tert-butyldimethylsilyl)oxy]-10,14,17,17-tetramethyl-3,7-dioxo-12-[(triethylsilyl)oxy]-2,4,8-trioxatetracyclo[11.3.1.0(1,5).0(6,10)]heptadec-13-en-9-yl]propanoate
Codes：(XVIII)101438-11-b
Application context (from source-drug indications)
乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Paclitaxel/Encequidar mesylatePaclitaxel/Encequidar mesylate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
methyl (1S,5S,6R,10S,11S,13R,16S)-16-[(tert-butyldimethylsilyl)oxy]-7,10-dihydroxy-11,15,18,18-tetramethyl-3-oxo-13-[(triethylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadeca-7,14-diene-8-carboxylate→(1S,5S,6R,9S,10S,12R,15S)-9-(but-3-en-1-yl)-15-[(tert-butyldimethylsilyl)oxy]-10,14,17,17-tetramethyl-12-[(triethylsilyl)oxy]-2,4,8-trioxatetracyclo[11.3.1.0(1,5).0(6,10)]heptadec-13-ene-3,7-dione→methyl 3-[(1S,5S,6R,9S,10S,12R,15S)-15-[(tert-butyldimethylsilyl)oxy]-10,14,17,17-tetramethyl-3,7-dioxo-12-[(triethylsilyl)oxy]-2,4,8-trioxatetracyclo[11.3.1.0(1,5).0(6,10)]heptadec-13-en-9-yl]propanoate→(1S,5S,6R,10S,11S,13R,16S)-16-[(tert-butyldimethylsilyl)oxy]-11,15,18,18-tetramethyl-10-(prop-1-en-2-yloxy)-13-[(triethylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-ene-3,7-dione→(1S,5S,6R,10S,11S,13R,16S)-16-[(tert-butyldimethylsilyl)oxy]-10-hydroxy-11,15,18,18-tetramethyl-13-[(triethylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-ene-3,7-dione→(1S,5S,6R,10S,11R,13R,16S)-10-[(benzyloxy)methyl]-16-[(tert-butyldimethylsilyl)oxy]-11,15,18,18-tetramethyl-13-[(triethylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-ene-3,7-dione→(1S,5S,6R,7S,8S,10S,11R,13R,16S)-10-[(benzyloxy)methyl]-16-[(tert-butyldimethylsilyl)oxy]-7-hydroxy-7-(hydroxymethyl)-11,15,18,18-tetramethyl-3-oxo-13-[(triethylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-8-yl 4-methylbenzene-1-sulfonate→(1S,5S,6S,10S,11R,13R,16S)-10-[(benzyloxy)methyl]-16-[(tert-butyldimethylsilyl)oxy]-11,15,18,18-tetramethyl-13-[(triethylsilyl)oxy]-7-[(trimethylsilyl)methyl]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadeca-7,14-dien-3-one→(1S,5S,6R,8S,10S,11R,13R,16S)-10-[(benzyloxy)methyl]-16-[(tert-butyldimethylsilyl)oxy]-11,15,18,18-tetramethyl-13-[(triethylsilyl)oxy]-8-[(trimethylsilyl)methyl]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-ene-3,7-dione→(3aS,5S,8S,9aR,10S,12S,13aS,13bS)-10-[(Benzyloxy)methyl]-5-[[tert-butyl(dimethyl)silyl]oxy]-12-hydroxy-6,9a,14,14-tetramethyl-13-methylidene-8-[(triethylsilyl)oxy]-5,8,9,9a,10,11,12,13,13a,13b-decahydro-2H,4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-2-one→(1S,5S,6R,7S,8S,10S,11R,13R,16S)-10-[(benzyloxy)methyl]-16-[(tert-butyldimethylsilyl)oxy]-7-hydroxy-7-(hydroxymethyl)-11,15,18,18-tetramethyl-3-oxo-13-[(triethylsilyl)oxy]-2,4-dioxatetracyclo[12.3.1.0(1,5).0(6,11)]octadec-14-en-8-yl methanesulfonate→(1S,5S,6R,7S,10R,12S,13R,15R,18S)-12-[(benzyloxy)methyl]-18-[(tert-butyldimethylsilyl)oxy]-7-hydroxy-13,17,20,20-tetramethyl-15-[(triethylsilyl)oxy]-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-3-one→(1S,5S,6R,7S,10R,12S,13R,15R,18S)-12-[(benzyloxy)methyl]-18-[(tert-butyldimethylsilyl)oxy]-13,17,20,20-tetramethyl-3-oxo-15-[(triethylsilyl)oxy]-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-7-yl acetate→(1S,5S,6R,7S,10R,12S,13R,15R,18S)-12-[(benzyloxy)methyl]-18-[(tert-butyldimethylsilyl)oxy]-15-hydroxy-13,17,20,20-tetramethyl-3-oxo-2,4,9-trioxapentacyclo[14.3.1.0(1,5).0(6,13).0(7,10)]icos-16-en-7-yl acetate→2-Methoxy-1-propene
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