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CAS 1541206-80-7
(6S)-6-((tert-butyldimethylsilyl)oxy)-1-(((1S,3aS,7aS,E)-1-((S)-1-hydroxyethyl)-7a-methyloctahydro-4H-inden-4-ylidene)methyl)-1,3,4,5,6,7-hexahydrobenzo[c]thiophene 2,2-dioxide
Codes: MAXA-053
Application context (from source-drug indications)
Secondary hyperparathyroidismMaxacalcitolHyperparathyroidismMaxacalcitol
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Maxacalcitol | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-(bromomethyl)-2,2-dimethyloxirane→(S,Z)-3-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexanol→tert-butyl(((S,Z)-3-(2-((1R,3aS,7aR,E)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexyl)oxy)dimethylsilane→2-((1R,3aS,7aR,E)-4-(((6S)-6-((tert-butyldimethylsilyl)oxy)-2,2-dioxido-1,3,4,5,6,7-hexahydrobenzo[c]thiophen-1-yl)methylene)-7a-methyloctahydro-1H-inden-1-yl)propanal→(2S)-2-((1R,3aS,7aR,E)-4-(((6S)-6-((tert-butyldimethylsilyl)oxy)-2,2-dioxido-1,3,4,5,6,7-hexahydrobenzo[c]thiophen-1-yl)methylene)-7a-methyloctahydro-1H-inden-1-yl)propanal→1-((1S,3aS,7aS,E)-4-(((6S)-6-((tert-butyldimethylsilyl)oxy)-2,2-dioxido-1,3,4,5,6,7-hexahydrobenzo[c]thiophen-1-yl)methylene)-7a-methyloctahydro-1H-inden-1-yl)ethan-1-one→(6S)-6-((tert-butyldimethylsilyl)oxy)-1-(((1S,3aS,7aS,E)-1-((S)-1-hydroxyethyl)-7a-methyloctahydro-4H-inden-4-ylidene)methyl)-1,3,4,5,6,7-hexahydrobenzo[c]thiophene 2,2-dioxide→(S)-1-((1S,3aS,7aS,E)-4-((E)-2-((S)-5-((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)ethan-1-ol→tert-butyl(((1S,E)-3-(2-((1S,3aS,7aS,E)-1-((1S)-1-((3,3-dimethyloxiran-2-yl)methoxy)ethyl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexyl)oxy)dimethylsilane→4-((S)-1-((1S,3aS,7aS,E)-4-((E)-2-((S)-5-((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)ethoxy)-2-methylbutan-2-ol→(1S,5R,E)-5-((tert-butyldimethylsilyl)oxy)-3-(2-((1S,3aS,7aS,E)-1-((S)-1-(3-hydroxy-3-methylbutoxy)ethyl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-2-methylenecyclohexan-1-ol→(1R,3S,E)-5-(2-((1S,3aS,7aS,E)-1-((S)-1-(3-hydroxy-3-methylbutoxy)ethyl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol→1-(anthracen-9-yl)ethan-1-one
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | PHOSPHINE OXIDE, [2-[3,5-BIS [[(1,1-DIMETHYLETHYL) DIMETHYLSILY]OXY]-2-METHYLENECYCLOHEXYLIDENE]ETHYL]DIPHENYL-,[3S-(1Z,3A,5B0)] Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | (1S,3aR,4S,7aS)-1-((S)-1-(3-hydroxy-3-methylbutoxy)ethyl)-7a-methyloctahydro-1H-inden-4-ol Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | (1S,3aR,7aR)-1-((S)-1-(3-hydroxy-3-Methylbutoxy)ethyl)-7a-Methylhexahydro-1H-inden-4(2H)-one Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | (1S,3aR,7aR)-Octahydro-7a-Methyl-1-((1S)-1-(3-Methyl-3-((triMethylsilyl)oxy)butoxy)ethyl)-4H-Inden-4-one Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | (Z)-2-((3S,5R)-3,5-bis((tert-butyldiMethylsilyl)oxy)-2-Methylenecyclohexylidene)ethanol Pharmaceutical Intermediates | On request | On request | On request | — |
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