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CAS 1542950-70-8

methyl ((1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carbonyl)(methyl)carbamate

Codes:TADA-010

Application context (from source-drug indications)

勃起功能障碍他达拉非/坦洛新前列腺增生他达拉非/坦洛新勃起功能障碍苯磺酸氨氯地平/他达拉非高血压苯磺酸氨氯地平/他达拉非

Source drugs (routes using this intermediate)

DrugTierExpiry
他达拉非/坦洛新Tadalafil/TamsulosinTier C — Watch / trade-
苯磺酸氨氯地平/他达拉非Amlodipine Besylate/TadalafilTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

他达拉非/坦洛新优化路线steps: 4total yield: 86 g
tryptophan→benzo[d][1,3]dioxole-5-carbaldehyde→tryptophanoyl chloride hydrochloride→methyl 2-(methyl-l2-azaneyl)acetate hydrochloride→methyl N-methyl-N-tryptophylglycinate hydrochloride→methyl ((1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carbonyl)(methyl)carbamate
苯磺酸氨氯地平/他达拉非优化路线steps: 4total yield: 86 g
tryptophan→benzo[d][1,3]dioxole-5-carbaldehyde→tryptophanoyl chloride hydrochloride→methyl 2-(methyl-l2-azaneyl)acetate hydrochloride→methyl N-methyl-N-tryptophylglycinate hydrochloride→methyl ((1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carbonyl)(methyl)carbamate

Intermediates available on this site

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