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CAS 155396-69-3
(2R,4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid
Codes：(XI)140605-15-a,(XI)140605-15-b、(IIIa)140605-23-a
Application context (from source-drug indications)
膀胱癌多西他赛纳米胶束 (Samyang Biopharmaceuticals)头颈癌多西他赛纳米胶束 (Samyang Biopharmaceuticals)头颈部鳞状细胞癌多西他赛纳米胶束 (Samyang Biopharmaceuticals)实体瘤多西他赛纳米胶束 (Samyang Biopharmaceuticals)
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 多西他赛纳米胶束 (Samyang Biopharmaceuticals)Docetaxel polymeric micelle (Samyang Biopharmaceuticals) | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(S)-(+)-2-Phenylglycine→tert-Butyl [(1S)-2-hydroxy-1-phenylethyl]carbamate→tert-Butyl [(1S)-2-cyano-2-hydroxy-1-phenylethyl]carbamate→Methyl (3S)-3-amino-2-hydroxy-3-phenylpropanoate hydrogen chloride (1/1)→Phosgene→Bis(1,1-dimethylethyl) dicarbonoate→3-tert-Butyl 5-methyl (4S,5R)-2-oxo-4-phenyl-1,3-oxazolidine-3,5-dicarboxylate→3(S)-(tert-Butoxycarbonylamino)-2(R)-hydroxy-3-phenylpropionic acid methyl ester→1-(Dimethoxymethyl)-4-methoxybenzene→(X)140605-15-a→(2R,4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid
(2alpha,5beta,7beta,10beta,13alpha)-4-(Acetyloxy)-1,7,10,13-tetrahydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-4-Acetoxy-1,13-dihydroxy-9-oxo-7,10-bis[[(2,2,2-trichloroethoxy)carbonyl]oxy]-5,20-epoxytax-11-en-2-yl benzoate→(2R,4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid→(4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid→5-[(2alpha,5beta,7beta,10beta,13alpha)-4-(Acetyloxy)-1-hydroxy-9-oxo-2-[(phenylcarbonyl)oxy]-7,10-bis[[(2,2,2-trichloroethoxy)carbonyl]oxy]-5,20-epoxytax-11-en-13-yl] 3-tert-butyl (2R,4S,5R)-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-3,5-dicarboxylate→5-[(2alpha,5beta,7beta,10beta,13alpha)-4-Acetoxy-2-(benzoyloxy)-1-hydroxy-9-oxo-7,10-bis[[(2,2,2-trichloroethoxy)carbonyl]oxy]-5,20-epoxytax-11-en-13-yl] 3-tert-butyl (4S,5R)-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-3,5-dicarboxylate→5-[(2alpha,5beta,7beta,10beta,13alpha)-4-(Acetyloxy)-1,7,10-trihydroxy-9-oxo-2-[(phenylcarbonyl)oxy]-5,20-epoxytax-11-en-13-yl] 3-tert-butyl (2R,4S,5R)-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-3,5-dicarboxylate
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